Histological sub?classification of cirrhosis using collagen proportionate area in patients with chronic hepatitis C

Collagen proportionate area (CPA, %) is used to quantify liver fibrosis. Here, we assessed CPA performance sub-classify cirrhosis. was measured in explanted livers from consecutively transplanted patients for hepatitis C virus-related Model end-stage disease (MELD), Child-Pugh score and decompensating events (ascites, variceal bleeding, non-obstructive jaundice encephalopathy) were recorded at the time of transplant. Of 154 patients, 24%, 12%, 35%, 24% 5% had zero, one, two, three four previous events. Patients with decompensation significantly higher than those without (25.1 ± 8.4 vs 15.8 5.5, P < .001). Decompensation independently associated CPA, bilirubin albumin or MELD score. did not differ between (22.2 6.3 26.6 8.9 24.5 7.7 24.4 10.9, = .242). Overall, correlates clinical severity cirrhosis until advent but subsequent